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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of designing a study, including the recruitment and consent process, as well as adherence and the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from various geographical areas. This type of heterogeneity, which is essential for pragmatic trials to be valid and lessen the chance of bias, is also necessary. However too much heterogeneity could result in problems with the design of the trial.

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Pragmatic trials are designed to replicate real-life situations and 무료 프라그마틱 attain maximum external validity. They are usually commissioned by practitioners and policy makers to inform their decision making. They also provide a useful way to identify the causality between an intervention and its results. They should, however, not, be used to replace explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic study, including the recruitment, design, and delivery of the intervention and its follow-up.

(Image: https://pragmatickr.com/wp-content/uploads/2024/05/98EBBC91ECA4-B2ECB48AECACA6EDB88AEA8C9DEDB8.png)The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to remember, however, that the majority of these studies were conducted in primary-care settings.